Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
FH Durie, RA Fava, TM Foy, A Aruffo, JA Ledbetter… - Science, 1993 - science.org
FH Durie, RA Fava, TM Foy, A Aruffo, JA Ledbetter, RJ Noelle
Science, 1993•science.orgThe ligand for the CD40 antigen is a 39-kilodalton protein, gp39, expressed on the surface
of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role
of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of
an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by
immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the
development of joint inflammation, serum antibody titers to collagen, the infiltration of …
of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role
of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of
an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by
immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the
development of joint inflammation, serum antibody titers to collagen, the infiltration of …
The ligand for the CD40 antigen is a 39-kilodalton protein, gp39, expressed on the surface of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the development of joint inflammation, serum antibody titers to collagen, the infiltration of inflammatory cells into the subsynovial tissue, and the erosion of cartilage and bone. Thus, interference with gp39-CD40 interactions may have therapeutic potential in the treatment of autoimmune disease.
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