Guilt by association: HLA-B27 and ankylosing spondylitis
R Benjamin, P Parham - Immunology today, 1990 - Elsevier
The remarkable association between HLA-B27 and ankylosing spondylitis (AS) remains an
enigma. While previous reviews have discussed the controversies surrounding the
involvement of bacteria in the etiology of this disease and the sequence variability between
subtypes of HLA-B27 (Ref. 3), concepts of disease mechanism remain ill-defined. In this
article Richard Benjamin and Peter Parham synthesize new data on the structure and
function of HLA class 1 molecules into possible mechanisms that might underly the …
enigma. While previous reviews have discussed the controversies surrounding the
involvement of bacteria in the etiology of this disease and the sequence variability between
subtypes of HLA-B27 (Ref. 3), concepts of disease mechanism remain ill-defined. In this
article Richard Benjamin and Peter Parham synthesize new data on the structure and
function of HLA class 1 molecules into possible mechanisms that might underly the …