[HTML][HTML] Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets

Z Xin, X Jiang, HY Wang, TN Denny, BN Dittel… - Regulatory peptides, 1997 - Elsevier
Intrathymic T cell precursors undergo a programmed sequence of developmental changes
resulting in the production of mature, self-MHC restricted, single positive T lymphocytes
which migrate to the periphery. The intrathymic T cell development is controlled by various
factors, including cytokines and possibly neuroendocrine hormones. Our previous studies
indicate that vasoactive intestinal peptide (VIP) inhibits IL-2 and IL-4 production in
thymocytes through different molecular mechanisms. Thymocytes acquire the competence to …