Conversion of the CD4+ T cell profile from Th2-dominant type to Th1-dominant type after varicella-zoster virus infection in atopic dermatitis
T Fujimura, R Yamanashi, M Masuzawa, Y Fujita… - Journal of allergy and …, 1997 - Elsevier
Skin lesions of atopic dermatitis were examined for cytokine expression by reverse
transcription-polymerase chain reaction. The profile of mRNA for various cytokines revealed
that both TH1 and TH2 types of CD4+ T cells, probably including TH0 type, infiltrate into the
skin lesion. We observed that atopic skin lesions improved after varicella infection. In such
lesions, expression of TH1 type cytokines predominated. The peripheral blood T cells from
atopic patients exhibited a differentiation into TH2 type cells upon in vitro stimulation with …
transcription-polymerase chain reaction. The profile of mRNA for various cytokines revealed
that both TH1 and TH2 types of CD4+ T cells, probably including TH0 type, infiltrate into the
skin lesion. We observed that atopic skin lesions improved after varicella infection. In such
lesions, expression of TH1 type cytokines predominated. The peripheral blood T cells from
atopic patients exhibited a differentiation into TH2 type cells upon in vitro stimulation with …