Atopic dermatitis (AD) is a common inflammatory skin disease with increasing prevalence
since World War II. Recent studies have shed light on how the complex interrelation of
genetic, environmental, immunologic, and pharmacologic factors contributes to the
development of AD. The current review will examine the cellular and immunologic
mechanisms underlying AD as well as the potential role of microbial superantigens in the
pathogenesis of AD. An understanding of the relative contributions of allergens, IgE, T cells …