CD4+ T-cell memory, CD45R subsets and the persistence of antigen—a unifying concept
EB Bell, SM Sparshott, C Bunce - Immunology today, 1998 - cell.com
EB Bell, SM Sparshott, C Bunce
Immunology today, 1998•cell.comThe cellular basis of immunological memory has been reassessed in the light of recent
evidence identifying two types of CD4+ memory T cell. Here, Eric Bell and colleagues argue
that two crucial components of memory—rapid recall and long life—belong not to one but to
two distinct subsets of CD4+ memory T cells: the CD45R lo and CD45R hi subsets,
respectively. Importantly, only the CD45R lo subset depends on persisting antigen.
evidence identifying two types of CD4+ memory T cell. Here, Eric Bell and colleagues argue
that two crucial components of memory—rapid recall and long life—belong not to one but to
two distinct subsets of CD4+ memory T cells: the CD45R lo and CD45R hi subsets,
respectively. Importantly, only the CD45R lo subset depends on persisting antigen.
Abstract
The cellular basis of immunological memory has been reassessed in the light of recent evidence identifying two types of CD4+ memory T cell. Here, Eric Bell and colleagues argue that two crucial components of memory—rapid recall and long life—belong not to one but to two distinct subsets of CD4+ memory T cells: the CD45Rlo and CD45Rhi subsets, respectively. Importantly, only the CD45Rlo subset depends on persisting antigen.
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