Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.
VG Sasseville, MM Smith, CR Mackay… - The American journal …, 1996 - ncbi.nlm.nih.gov
The American journal of pathology, 1996•ncbi.nlm.nih.gov
The pathogenesis of neurological dysfunction associated with human immunodeficiency
(HIV)-1 infection is uncertain. However, the presence of macrophage infiltrates in the central
nervous system is a key feature of HIV encephalitis and is correlated with HIV-associated
dementia. Moreover, it has been demonstrated that HIV-infected monocyte/macrophages
can produce toxic substances that may play a critical role in the development of HIV-
associated dementia. However, the exact mechanisms responsible for HIV infection and …
(HIV)-1 infection is uncertain. However, the presence of macrophage infiltrates in the central
nervous system is a key feature of HIV encephalitis and is correlated with HIV-associated
dementia. Moreover, it has been demonstrated that HIV-infected monocyte/macrophages
can produce toxic substances that may play a critical role in the development of HIV-
associated dementia. However, the exact mechanisms responsible for HIV infection and …
Abstract
The pathogenesis of neurological dysfunction associated with human immunodeficiency (HIV)-1 infection is uncertain. However, the presence of macrophage infiltrates in the central nervous system is a key feature of HIV encephalitis and is correlated with HIV-associated dementia. Moreover, it has been demonstrated that HIV-infected monocyte/macrophages can produce toxic substances that may play a critical role in the development of HIV-associated dementia. However, the exact mechanisms responsible for HIV infection and leukocyte recruitment to the central nervous system remain speculative. Similar to HIV-infected patients, simian immunodeficiency virus (SIV)-infected macaque monkeys develop immunosuppression and acquired immune deficiency syndrome (AIDS)-related inflammatory disorders, including AIDS encephalitis. In this study, we demonstrate that encephalitic brain from SIV-infected animals has elevated immunohistochemical expression of the CC chemokines, macrophage inflammatory protein-1 alpha and-beta, RANTES, and monocyte chemotactic protein-3, and the CXC chemokine interferon-inducible protein-10. These findings suggest that one or all of of these chemokines could be involved in leukocyte recruitment to the brain in SIV-infected macaque monkeys.
ncbi.nlm.nih.gov