[HTML][HTML] Transgenic mice that overexpress mouse apolipoprotein B: Evidence that the dna sequences controlling intestinal expression of the apolipoprotein B gene …
SPA McCormick, JK Ng, M Véniant, J Borén… - Journal of Biological …, 1996 - ASBMB
An 87-kilobase (kb) P1 bacteriophage clone (p649) spanning the mouse apolipoprotein
(apo) B gene was used to generate transgenic mice that express high levels of mouse apoB.
Plasma levels of apoB, low density lipoprotein cholesterol, and low density lipoprotein
triglycerides were increased, and high density lipoprotein cholesterol levels were decreased
in the transgenic mice, compared with nontransgenic littermate controls. Although p649
contained 33 kb of 5′-flanking sequences and 11 kb of 3′-flanking sequences, the tissue …
(apo) B gene was used to generate transgenic mice that express high levels of mouse apoB.
Plasma levels of apoB, low density lipoprotein cholesterol, and low density lipoprotein
triglycerides were increased, and high density lipoprotein cholesterol levels were decreased
in the transgenic mice, compared with nontransgenic littermate controls. Although p649
contained 33 kb of 5′-flanking sequences and 11 kb of 3′-flanking sequences, the tissue …