Vα14+ NK T cells: A novel lymphoid cell lineage with regulatory function
M Taniguchi, Y Makino, J Cui, K Masuda… - Journal of allergy and …, 1996 - Elsevier
A novel lymphoid lineage, NK T cells, was recently found. The NK T cells are the major
population in the periphery comprising 5% of splenic T cells and 40% of bone marrow T
cells. They express a unique TCR composed of invariant Vα14Jα281 and Vβ8. 2 together
with NK receptor (NKRPI). Surprisingly, the invariant Vα14+ TCR is exclusively expressed
on NK T cells but not on conventional T cells. As the selective decrease in Vα14+ NK T cell
population in the periphery is tightly correlated with autoimmune disease development …
population in the periphery comprising 5% of splenic T cells and 40% of bone marrow T
cells. They express a unique TCR composed of invariant Vα14Jα281 and Vβ8. 2 together
with NK receptor (NKRPI). Surprisingly, the invariant Vα14+ TCR is exclusively expressed
on NK T cells but not on conventional T cells. As the selective decrease in Vα14+ NK T cell
population in the periphery is tightly correlated with autoimmune disease development …