Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy
The Journal of experimental medicine, 1997•rupress.org
Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and
other T cell mediated, inflammatory skin diseases. In the present study, successful
phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis
in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro,
UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-
ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen …
other T cell mediated, inflammatory skin diseases. In the present study, successful
phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis
in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro,
UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-
ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen …
Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy.
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