[HTML][HTML] ATP depletion induces a loss of respiratory epithelium functional integrity and down-regulates CFTR (cystic fibrosis transmembrane conductance regulator) …
S Brézillon, JM Zahm, D Pierrot, D Gaillard… - Journal of Biological …, 1997 - ASBMB
To mimic the effect of ischemia on the integrity of airway epithelium and expression of cystic
fibrosis transmembrane conductance regulator (CFTR), we induced an ATP depletion of the
respiratory epithelium from upper airway cells (nasal tissue) and human bronchial epithelial
16HBE14o− cell line. Histological analysis showed that 2 h of ATP depletion led to a loss of
the epithelium integrity at the interface between basal cells and columnar cells. The
expression of connexin 43 (Cx43, subunit of the gap junctions) and desmoplakins 1 and 2 …
fibrosis transmembrane conductance regulator (CFTR), we induced an ATP depletion of the
respiratory epithelium from upper airway cells (nasal tissue) and human bronchial epithelial
16HBE14o− cell line. Histological analysis showed that 2 h of ATP depletion led to a loss of
the epithelium integrity at the interface between basal cells and columnar cells. The
expression of connexin 43 (Cx43, subunit of the gap junctions) and desmoplakins 1 and 2 …