Interleukin-4 as a potent inhibitor of bone resorption
K Watanabe, Y Tanaka, I Morimoto, K Yahata… - Biochemical and …, 1990 - Elsevier
K Watanabe, Y Tanaka, I Morimoto, K Yahata, K Zeki, T Fujihira, U Yamashita, S Eto
Biochemical and biophysical research communications, 1990•ElsevierA possible role of interleukin-4 (IL-4) in the regulation of bone turnover was assessed by
employing a 45 Ca prelabeled-fetal mouse long bone culture system. IL-4 inhibited the bone
resorption stimulated by parathyroid hormone (PTH), PTH related protein (PTHrP), 1α, 25,
dihydroxy-vitamine D 3 [1α, 25 (OH) 2 D 3], interleukin-1α and− 1β (IL-1α, IL-1β) and
prostaglandin E 2 (PGE 2). Anti-IL-4 monoclonal antibody abolished the inhibitory effect of IL-
4 on the bone resorption. These results suggest that IL-4 may play an important role on the …
employing a 45 Ca prelabeled-fetal mouse long bone culture system. IL-4 inhibited the bone
resorption stimulated by parathyroid hormone (PTH), PTH related protein (PTHrP), 1α, 25,
dihydroxy-vitamine D 3 [1α, 25 (OH) 2 D 3], interleukin-1α and− 1β (IL-1α, IL-1β) and
prostaglandin E 2 (PGE 2). Anti-IL-4 monoclonal antibody abolished the inhibitory effect of IL-
4 on the bone resorption. These results suggest that IL-4 may play an important role on the …
Abstract
A possible role of interleukin-4 (IL-4) in the regulation of bone turnover was assessed by employing a 45Ca prelabeled-fetal mouse long bone culture system. IL-4 inhibited the bone resorption stimulated by parathyroid hormone (PTH), PTH related protein (PTHrP), 1α,25,dihydroxy-vitamine D3[1α,25(OH)2D3], interleukin-1α and −1β (IL-1α, IL-1β) and prostaglandin E2(PGE2). Anti-IL-4 monoclonal antibody abolished the inhibitory effect of IL-4 on the bone resorption. These results suggest that IL-4 may play an important role on the inhibitory regulation of bone resorption.
Elsevier