Previous functional studies have demonstrated that muscle intracellular pH regulation is
mediated by sodium-coupled bicarbonate transport, Na+/H+ exchange, and Cl−/bicarbonate
exchange. We report the cloning, sequence analysis, tissue distribution, genomic
organization, and functional analysis of a new member of the sodium bicarbonate
cotransporter (NBC) family, NBC3, from human skeletal muscle. mNBC3 encodes a 1214-
residue polypeptide with 12 putative membrane-spanning domains. The∼ 7.8-kilobase …