[HTML][HTML] Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases
ML Corcoran, MC Kibbey, HK Kleinman… - Journal of Biological …, 1995 - ASBMB
The laminin-derived synthetic peptide containing the SIKVAV (Ser-Ile-Lys-Val-Ala-Val)
amino acid sequence has been previously shown to regulate tumor invasion, metastasis,
and angiogenesis. Here, we demonstate that this peptide also modulates human monocyte
responses. Moreover, the monocytic responses elicited by this peptide are influenced by the
culture conditions. When elutriated monocytes were cultured on SIKVAV substrate or in
suspension with this peptide, the synthesis of prostaglandin E 2, interstitial collagenase, and …
amino acid sequence has been previously shown to regulate tumor invasion, metastasis,
and angiogenesis. Here, we demonstate that this peptide also modulates human monocyte
responses. Moreover, the monocytic responses elicited by this peptide are influenced by the
culture conditions. When elutriated monocytes were cultured on SIKVAV substrate or in
suspension with this peptide, the synthesis of prostaglandin E 2, interstitial collagenase, and …