[HTML][HTML] p38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II: role in vascular smooth …
M Ushio-Fukai, RW Alexander, M Akers… - Journal of Biological …, 1998 - ASBMB
Angiotensin II induces an oxidant stress-dependent hypertrophy in cultured vascular smooth
muscle cells. To investigate the growth-related molecular targets of H 2 O 2, we examined
the redox sensitivity of agonist-stimulated activation of the mitogen-activated protein kinase
(MAPK) family. We show here that angiotensin II elicits a rapid increase in intracellular H 2 O
2 and a rapid and robust phosphorylation of both p42/44MAPK (16-fold) and p38MAPK (15-
fold). However, exogenous H 2 O 2 activates only p38MAPK (14-fold), and diphenylene …
muscle cells. To investigate the growth-related molecular targets of H 2 O 2, we examined
the redox sensitivity of agonist-stimulated activation of the mitogen-activated protein kinase
(MAPK) family. We show here that angiotensin II elicits a rapid increase in intracellular H 2 O
2 and a rapid and robust phosphorylation of both p42/44MAPK (16-fold) and p38MAPK (15-
fold). However, exogenous H 2 O 2 activates only p38MAPK (14-fold), and diphenylene …