Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor
GS Shukla, A Shukla, J Inokuchi, NS Radin - Biochimica et Biophysica Acta …, 1991 - Elsevier
The ceramide analog, d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-morpholino-1-
propanol, inhibits the glucosylation of ceramide and thus, by virtue of the normal catabolism
of the higher glucosphingolipids, leads to a general depletion of cellular glucolipids. In a
previous study with chronic administration of this inhibitor in mice, it was found that the
kidneys and liver, particularly the former, grew more poorly than the organs of control mice.
This study shows that the inhibitor produces rapid decreases in glucolipid concentration in …
propanol, inhibits the glucosylation of ceramide and thus, by virtue of the normal catabolism
of the higher glucosphingolipids, leads to a general depletion of cellular glucolipids. In a
previous study with chronic administration of this inhibitor in mice, it was found that the
kidneys and liver, particularly the former, grew more poorly than the organs of control mice.
This study shows that the inhibitor produces rapid decreases in glucolipid concentration in …