Integrins: emerging paradigms of signal transduction
MA Schwartz, MD Schaller… - Annual review of cell and …, 1995 - annualreviews.org
MA Schwartz, MD Schaller, MH Ginsberg
Annual review of cell and developmental biology, 1995•annualreviews.orgIntegrins receive signals from other receptors that lead to activation of ligand binding (inside-
out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular
signaling pathways. These signals converse with pathways that are initiated by soluble
ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events
to orchestrate complex cellular behavior.
out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular
signaling pathways. These signals converse with pathways that are initiated by soluble
ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events
to orchestrate complex cellular behavior.
Abstract
Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular signaling pathways. These signals converse with pathways that are initiated by soluble ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events to orchestrate complex cellular behavior.
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