[HTML][HTML] Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize α-amino acids to a family of reactive aldehydes: Mechanistic …
We have recently demonstrated that neutrophils oxidize nearly all of the amino acids
commonly found in plasma to a corresponding family of aldehydes in high yield. The
reaction is mediated by hypochlorous acid (HOCl), the major oxidant generated by the
myeloperoxidase-H 2 O 2-Cl− system of phagocytes. We now present evidence for the
underlying mechanism of this reaction, including the structural requirements and reaction
intermediates formed. Utilizing mass spectrometry and isotopically labeled amino acids, we …
commonly found in plasma to a corresponding family of aldehydes in high yield. The
reaction is mediated by hypochlorous acid (HOCl), the major oxidant generated by the
myeloperoxidase-H 2 O 2-Cl− system of phagocytes. We now present evidence for the
underlying mechanism of this reaction, including the structural requirements and reaction
intermediates formed. Utilizing mass spectrometry and isotopically labeled amino acids, we …