Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response
SAA Comhair, PR Bhathena, RA Dweik, M Kavuru… - The Lancet, 2000 - thelancet.com
SAA Comhair, PR Bhathena, RA Dweik, M Kavuru, SC Erzurum
The Lancet, 2000•thelancet.comLoss of superoxide dismutase activity occurs within minutes of an acute asthmatic response
to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased
activity undoubtedly contributes to airway inflammation and injury through increased
formation of reactive oxygen and nitrogen species, and suggests that enrichment of lung
antioxidants is therapeutic for asthma.
to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased
activity undoubtedly contributes to airway inflammation and injury through increased
formation of reactive oxygen and nitrogen species, and suggests that enrichment of lung
antioxidants is therapeutic for asthma.
Summary
Loss of superoxide dismutase activity occurs within minutes of an acute asthmatic response to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased activity undoubtedly contributes to airway inflammation and injury through increased formation of reactive oxygen and nitrogen species, and suggests that enrichment of lung antioxidants is therapeutic for asthma.
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