Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness
HR Smith, GL Larsen, RM Cherniack… - Journal of Allergy and …, 1992 - Elsevier
To determine the relationship of inflammatory cells and eicosanoid mediators to the
pathogenesis of the late asthmatic response (LAR) and increases in nonspecific airway
responsiveness, we studied bronchoalveolar lavage (BAL) cells and fluid in 27 subjects 12
hours after inhaled antigen challenge. Methacholine challenge was performed before
antigen challenge and 24 hours later (12 hours after BAL). Eight subjects had no LAR (−
LAR,≤ 10% fall in FEV 1), nine subjects had an equivocal LAR (±LAR, 11% 25% fall in FEV …
pathogenesis of the late asthmatic response (LAR) and increases in nonspecific airway
responsiveness, we studied bronchoalveolar lavage (BAL) cells and fluid in 27 subjects 12
hours after inhaled antigen challenge. Methacholine challenge was performed before
antigen challenge and 24 hours later (12 hours after BAL). Eight subjects had no LAR (−
LAR,≤ 10% fall in FEV 1), nine subjects had an equivocal LAR (±LAR, 11% 25% fall in FEV …