[HTML][HTML] A role for nuclear factor κB in the antiapoptotic function of insulin
F Bertrand, A Atfi, A Cadoret, G L'Allemain… - Journal of Biological …, 1998 - ASBMB
We previously reported that insulin activates nuclear factor κB (NF-κB) in Chinese hamster
ovary (CHO)-R cells overexpressing wild-type insulin receptors (IRs) through a pathway
requiring IR tyrosine kinase and Raf-1 kinase activities. We now investigated whether the
activation of NF-κB by insulin could serve an antiapoptotic function. Insulin (10− 9-10− 7 m)
inhibited apoptosis induced by serum withdrawal in CHO-R cells in a concentration-
dependent manner. Insulin antiapoptotic signaling:(i) was dependent on IR number and IR …
ovary (CHO)-R cells overexpressing wild-type insulin receptors (IRs) through a pathway
requiring IR tyrosine kinase and Raf-1 kinase activities. We now investigated whether the
activation of NF-κB by insulin could serve an antiapoptotic function. Insulin (10− 9-10− 7 m)
inhibited apoptosis induced by serum withdrawal in CHO-R cells in a concentration-
dependent manner. Insulin antiapoptotic signaling:(i) was dependent on IR number and IR …