Natural killer cell receptors and MHC class I interactions
LL Lanier - Current opinion in immunology, 1997 - Elsevier
Current opinion in immunology, 1997•Elsevier
Natural killer cells express two distinct families of genes encoding receptors for polymorphic
MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based
inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49
receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2,
resulting in inhibition of natural-killer-and T-cell-mediated cytotoxicity and cytokine secretion.
MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based
inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49
receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2,
resulting in inhibition of natural-killer-and T-cell-mediated cytotoxicity and cytokine secretion.
Natural killer cells express two distinct families of genes encoding receptors for polymorphic MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49 receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2, resulting in inhibition of natural-killer- and T-cell-mediated cytotoxicity and cytokine secretion.
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