Effects of pertussis toxin onα 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes
JS Karliner, T Kagiya, PC Simpson - Experientia, 1990 - Springer
JS Karliner, T Kagiya, PC Simpson
Experientia, 1990•SpringerIn neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 μM (−)-
norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as
measured either by protein radiolabelling or by myocardial cell protein content. Thus
guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in two α
1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of
myocardial cell hypertrophy.
norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as
measured either by protein radiolabelling or by myocardial cell protein content. Thus
guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in two α
1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of
myocardial cell hypertrophy.
Summary
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 μM (−)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in twoα 1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.
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