Effects of pertussis toxin onα 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes

JS Karliner, T Kagiya, PC Simpson - Experientia, 1990 - Springer
JS Karliner, T Kagiya, PC Simpson
Experientia, 1990Springer
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 μM (−)-
norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as
measured either by protein radiolabelling or by myocardial cell protein content. Thus
guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in two α
1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of
myocardial cell hypertrophy.
Summary
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 μM (−)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in twoα 1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.
Springer