FLT3 ligand (FL) is a recently described hematopoietic growth factor that stimulates the
proliferation and differentiation of hematopoietic progenitors. We have investigated the effect
of FL on murine hematopoiesis and dendritic cell (DC) generation and accumulation in
lymphoid tissues and liverin vivoandin vitroevaluating the morphologic, phenotypic, and
functional characteristics of these DC. We have observed extramedullary hematopoiesis in
the mouse spleen with all lineages of hematopoietic cells represented after the …