[PDF][PDF] Interleukin 10–mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum
M Plebanski, KL Flanagan, EAM Lee, WHH Reece… - Immunity, 1999 - cell.com
Immunity, 1999•cell.com
The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of
Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the
parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that
costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid
change from IFNγ production to the immunosuppresive mediator interleukin 10 (IL-10). This
mechanism may contribute to the low levels of T cell responses observed to this pathogen in …
Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the
parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that
costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid
change from IFNγ production to the immunosuppresive mediator interleukin 10 (IL-10). This
mechanism may contribute to the low levels of T cell responses observed to this pathogen in …
Abstract
The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNγ production to the immunosuppresive mediator interleukin 10 (IL-10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.
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