[45] Transport function and substrate specificity of multidrug resistance protein
D Keppler, G Jedlitschky, I Leier - Methods in enzymology, 1998 - Elsevier
Publisher Summary This chapter describes the multidrug resistance protein (MRP1) that has
been cloned and sequenced from multidrug-resistant human lung cancer cells and identified
as an integral membrane glycoprotein belonging to the superfamily of adenosine
triphosphate-binding cassette (ABC) transporters. Primary active unidirectional adenosine
triphosphate (ATP)-dependent transport of amphiphilic anions—in particular, of conjugates
of lipophilic substances with glutathione, glucuronate, or sulfate, are the recognized …
been cloned and sequenced from multidrug-resistant human lung cancer cells and identified
as an integral membrane glycoprotein belonging to the superfamily of adenosine
triphosphate-binding cassette (ABC) transporters. Primary active unidirectional adenosine
triphosphate (ATP)-dependent transport of amphiphilic anions—in particular, of conjugates
of lipophilic substances with glutathione, glucuronate, or sulfate, are the recognized …