NPY-Y1 receptor antisense injected centrally in rats causes hyperthermia and feeding
FJ Lopez-Valpuesta, JW Nyce, RD Myers - Neuroreport, 1996 - journals.lww.com
THE central actions of neuropeptide Y antisense oligodeoxynucleotide (aNPY) and NPY-Y1
receptor antisense (aNPY-Y1) on body temperature (T b), feeding and body weight of
unrestrained rats were determined by the repeated intracerebroventricular (icv) injection of
0.5 μg doses. aNPY-Y1 caused intense phasic rises in T b, lowered body weight and caused
transient feeding. aNPY increased food intake paradoxically, accompanied by a gain in
body weight but did not affect T b. Circadian activity was unaffected by either antisense …
receptor antisense (aNPY-Y1) on body temperature (T b), feeding and body weight of
unrestrained rats were determined by the repeated intracerebroventricular (icv) injection of
0.5 μg doses. aNPY-Y1 caused intense phasic rises in T b, lowered body weight and caused
transient feeding. aNPY increased food intake paradoxically, accompanied by a gain in
body weight but did not affect T b. Circadian activity was unaffected by either antisense …