Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain
PS Kalra, MG Dube, B Xu, SP Kalra - Regulatory peptides, 1997 - Elsevier
Disruption of neural signaling by microinjection of a neurotoxin, colchicine (COL), in the
ventromedial hypothalamus (VMH) of rats results in rapid and transient hyperphagia and
body weight gain. Since neuropeptide Y (NPY) is a potent hypothalamic orexigenic signal
and continuous NPY receptor activation by intracerebroventricular (icv) NPY infusion results
in hyperphagia and obesity, we tested the hypothesis that altered NPYergic signaling may
underlie the transient hyperphagia in COL-injected rats. Immediately following COL (4 μg) …
ventromedial hypothalamus (VMH) of rats results in rapid and transient hyperphagia and
body weight gain. Since neuropeptide Y (NPY) is a potent hypothalamic orexigenic signal
and continuous NPY receptor activation by intracerebroventricular (icv) NPY infusion results
in hyperphagia and obesity, we tested the hypothesis that altered NPYergic signaling may
underlie the transient hyperphagia in COL-injected rats. Immediately following COL (4 μg) …