Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats
H Lu, Z Duanmu, C Houck, KLC Jen, A Buison… - Brain research …, 1998 - Elsevier
Obesity is associated with an increase in plasma leptin levels primarily derived from
enhanced expression of the leptin gene in the adipose tissue. Leptin levels and expression
are higher in females than males. The main functions of leptin are to decrease food intake
and increase sympathetic nerve activity, especially in the brown adipose tissue. The high
levels of leptin in obese, female rats suggest leptin resistance. In this article we describe
experiments designed to investigate the effect of the intracerebroventricular (icv) …
enhanced expression of the leptin gene in the adipose tissue. Leptin levels and expression
are higher in females than males. The main functions of leptin are to decrease food intake
and increase sympathetic nerve activity, especially in the brown adipose tissue. The high
levels of leptin in obese, female rats suggest leptin resistance. In this article we describe
experiments designed to investigate the effect of the intracerebroventricular (icv) …