[HTML][HTML] Fas-or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
B Brenner, U Koppenhoefer, C Weinstock… - Journal of Biological …, 1997 - ASBMB
In the present study, we show that Fas receptor ligation or cellular treatment with synthetic C
6-ceramide results in activation or phosphorylation, respectively, of the small G-protein
Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the transcription factor
GADD153. A signaling cascade from the Fas receptor via ceramide, Ras, Rac1, and
JNK/p38-K to GADD153 is demonstrated employing transfection of transdominant inhibitory
N17Ras, N17Rac1, c-Jun, or treatment with a specific p38-K inhibitor. The critical function of …
6-ceramide results in activation or phosphorylation, respectively, of the small G-protein
Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the transcription factor
GADD153. A signaling cascade from the Fas receptor via ceramide, Ras, Rac1, and
JNK/p38-K to GADD153 is demonstrated employing transfection of transdominant inhibitory
N17Ras, N17Rac1, c-Jun, or treatment with a specific p38-K inhibitor. The critical function of …