[HTML][HTML] Prodrug-activating systems in suicide gene therapy

CJ Springer, I Niculescu-Duvaz - The Journal of clinical …, 2000 - Am Soc Clin Investig
CJ Springer, I Niculescu-Duvaz
The Journal of clinical investigation, 2000Am Soc Clin Investig
GDEPT, a form of suicide gene therapy, aims to maximize the effect of a toxic drug and
minimize its systemic effects by generating the drug in situ within the tumor. In the first step in
this procedure, the gene for an exogenous enzyme is delivered and expressed in the tumor
cells. Subsequently, a prodrug is administered that is converted to the active drug by the
foreign enzyme expressed inside or on the surface of tumor cells.
GDEPT, a form of suicide gene therapy, aims to maximize the effect of a toxic drug and minimize its systemic effects by generating the drug in situ within the tumor. In the first step in this procedure, the gene for an exogenous enzyme is delivered and expressed in the tumor cells. Subsequently, a prodrug is administered that is converted to the active drug by the foreign enzyme expressed inside or on the surface of tumor cells.
The Journal of Clinical Investigation