[CITATION][C] Cancer immunotherapy by direct in vivo transfer of immunomodulatory genes
P Leroy, P Slos, H Homann, P Erbs, Y Poitevin… - Research in …, 1998 - Elsevier
MHC-class I-positive cells expose on their surface thousands of self peptides derived from
endogenous cellular or viral proteins, which constitute antigen determinants potentially
recognized by T cells (Townsend and Allison, 1993). In the particular case of tumour cells,
tumour-specific peptides can similarly be presented to the immune system, either as
peptides derived from overexpressed native proteins or as peptides derived from mutated
proteins (Van Den Brnggen et al., 1991). Cancer cells can therefore constitute potential …
endogenous cellular or viral proteins, which constitute antigen determinants potentially
recognized by T cells (Townsend and Allison, 1993). In the particular case of tumour cells,
tumour-specific peptides can similarly be presented to the immune system, either as
peptides derived from overexpressed native proteins or as peptides derived from mutated
proteins (Van Den Brnggen et al., 1991). Cancer cells can therefore constitute potential …