[HTML][HTML] Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase
S Nemoto, J Xiang, S Huang, A Lin - Journal of Biological Chemistry, 1998 - ASBMB
p38, a subfamily of the mitogen-activated protein kinase, regulates gene expression in
response to various extracellular stimuli. The pyridinyl imidazoles like SB202190 are
specific inhibitors of p38α and p38β and have been widely used in investigation of the
biological functions of p38. Here we show that SB202190 by itself was sufficient to induce
cell death, with typical apoptotic features such as nucleus condensation and
intranucleosomal DNA fragmentation. SB202190 stimulated the activity of CPP32-like …
response to various extracellular stimuli. The pyridinyl imidazoles like SB202190 are
specific inhibitors of p38α and p38β and have been widely used in investigation of the
biological functions of p38. Here we show that SB202190 by itself was sufficient to induce
cell death, with typical apoptotic features such as nucleus condensation and
intranucleosomal DNA fragmentation. SB202190 stimulated the activity of CPP32-like …