[HTML][HTML] Sounding the alarm: protein kinase cascades activated by stress and inflammation
JM Kyriakis, J Avruch - Journal of Biological Chemistry, 1996 - ASBMB
Eukaryotic cells respond to extracellular stimuli by recruiting signal transduction pathways,
many of which employ protein Ser/Thr kinases of the ERK1 family. The ubiquity of ERKs and
their upstream activators, the MEKs, in signal transduction was first appreciated from studies
of yeast (1, 2). Although a 54-kDa rat liver c-Jun kinase (SAPK-p541) with properties similar
to the Rasregulated MAPKs had been characterized (3–5), the physiologic roles and
regulation of this and related mammalian enzymes have emerged only recently. Molecular …
many of which employ protein Ser/Thr kinases of the ERK1 family. The ubiquity of ERKs and
their upstream activators, the MEKs, in signal transduction was first appreciated from studies
of yeast (1, 2). Although a 54-kDa rat liver c-Jun kinase (SAPK-p541) with properties similar
to the Rasregulated MAPKs had been characterized (3–5), the physiologic roles and
regulation of this and related mammalian enzymes have emerged only recently. Molecular …