Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions
G Le Gros, F Erard - Current opinion in immunology, 1994 - Elsevier
G Le Gros, F Erard
Current opinion in immunology, 1994•ElsevierCD8+ T cells activated in the presence of IL-4 can develop into distinct, non-cytotoxic CD8−
and cytotoxic CD8+ subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-γ. These
'Th2 like'CD8+ cells may enhance Th2 responses, help B cells or suppress Th1 immune
responses. Importantly, the switch from the cytotoxic, IFN-γ producing CD8+ T-cell
phenotype could compromise the host response to infectious agents such as HIV.
and cytotoxic CD8+ subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-γ. These
'Th2 like'CD8+ cells may enhance Th2 responses, help B cells or suppress Th1 immune
responses. Importantly, the switch from the cytotoxic, IFN-γ producing CD8+ T-cell
phenotype could compromise the host response to infectious agents such as HIV.
Abstract
CD8+ T cells activated in the presence of IL-4 can develop into distinct, non-cytotoxic CD8− and cytotoxic CD8+ subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-γ. These ‘Th2 like’ CD8+ cells may enhance Th2 responses, help B cells or suppress Th1 immune responses. Importantly, the switch from the cytotoxic, IFN-γ producing CD8+ T-cell phenotype could compromise the host response to infectious agents such as HIV.
Elsevier