[HTML][HTML] Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products
J Li, AM Schmidt - Journal of Biological Chemistry, 1997 - ASBMB
The receptor for advanced glycation end products, RAGE, is a member of the
immunoglobulin superfamily of cell surface molecules differentially expressed on a range of
cell types. Ligation of RAGE perturbs homeostatic mechanisms and, potentially, provides a
basis for cellular dysfunction in pathologic situations in which its ligands accumulate. To
understand factors underlying RAGE expression, we cloned the 5′-flanking region of the
RAGE gene and characterized putative regulatory motifs. Analysis of the putative promoter …
immunoglobulin superfamily of cell surface molecules differentially expressed on a range of
cell types. Ligation of RAGE perturbs homeostatic mechanisms and, potentially, provides a
basis for cellular dysfunction in pathologic situations in which its ligands accumulate. To
understand factors underlying RAGE expression, we cloned the 5′-flanking region of the
RAGE gene and characterized putative regulatory motifs. Analysis of the putative promoter …