The S100 family of EF-hand calcium-binding proteins: functions and pathology
BW Schäfer, CW Heizmann - Trends in biochemical sciences, 1996 - cell.com
BW Schäfer, CW Heizmann
Trends in biochemical sciences, 1996•cell.comCalcium ions as second messengers control many biological processes, at least in part, via
interaction with a large number of Ca 2+-binding proteins. One class of these proteins
shares a common Ca 2+-binding motif, the EF-hand. Here, we describe some functional
aspects of EF-hand proteins, which have been found recently in different cellular
compartments. Novel links between EF-hand proteins, particularly S100 proteins, and
specific diseases are now emerging.
interaction with a large number of Ca 2+-binding proteins. One class of these proteins
shares a common Ca 2+-binding motif, the EF-hand. Here, we describe some functional
aspects of EF-hand proteins, which have been found recently in different cellular
compartments. Novel links between EF-hand proteins, particularly S100 proteins, and
specific diseases are now emerging.
Calcium ions as second messengers control many biological processes, at least in part, via interaction with a large number of Ca2+-binding proteins. One class of these proteins shares a common Ca2+-binding motif, the EF-hand. Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.
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