[HTML][HTML] Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells
JF Tait, C Smith - Journal of Biological Chemistry, 1999 - ASBMB
Exposure of phosphatidylserine (PtdSer) has been implicated in the recognition and
phagocytosis of senescent and apoptotic cells, and CD36 has been proposed as one
receptor protein that recognizes PtdSer and other anionic phospholipids. We investigated
the binding of phospholipid vesicles to the monocytic leukemia cell lines THP-1 and J774A.
1 with a flow cytometric assay; vesicles contained 50 mol% PtdSer, phosphatidylinositol
(PtdIns), or phosphatidylglycerol (PtdGro), with the balance being phosphatidylcholine …
phagocytosis of senescent and apoptotic cells, and CD36 has been proposed as one
receptor protein that recognizes PtdSer and other anionic phospholipids. We investigated
the binding of phospholipid vesicles to the monocytic leukemia cell lines THP-1 and J774A.
1 with a flow cytometric assay; vesicles contained 50 mol% PtdSer, phosphatidylinositol
(PtdIns), or phosphatidylglycerol (PtdGro), with the balance being phosphatidylcholine …