Singlet excited oxygen as a mediator of the antibacterial action of leukocytes

NI Krinsky - Science, 1974 - science.org
NI Krinsky
Science, 1974science.org
Human polymorphonuclear leukocytes kill a colorless mutant strain of Sarcina lutea much
more readily than a carotenoid-containing strain. A similar protective effect has been
reported in the organism during photodynamic inactivation, where it is attributable to the
quenching of singlet excited oxygen by carotenoids. The findings with leukocytes support
the suggestion that singlet excited oxygen acts as one of the mediators of their bactericidal
action.
Human polymorphonuclear leukocytes kill a colorless mutant strain of Sarcina lutea much more readily than a carotenoid-containing strain. A similar protective effect has been reported in the organism during photodynamic inactivation, where it is attributable to the quenching of singlet excited oxygen by carotenoids. The findings with leukocytes support the suggestion that singlet excited oxygen acts as one of the mediators of their bactericidal action.
AAAS