[HTML][HTML] Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1
Q Chen, M Galleano, AI Cederbaum - Journal of Biological Chemistry, 1997 - ASBMB
The goal of the current study was to evaluate the effects of arachidonic acid, as a
representative polyunsaturated fatty acid, on the viability of a Hep G2 cell line, which has
been transduced to express human cytochrome P4502E1 (CYP2E1). Arachidonic acid
produced a concentration-and time-dependent toxicity to Hep G2-MV2E1-9 cells, which
express CYP2E1, but little or no toxicity was found with control Hep G2-MV-5 cells, which
were infected with retrovirus lacking human CYP2E1 cDNA. In contrast to arachidonic acid …
representative polyunsaturated fatty acid, on the viability of a Hep G2 cell line, which has
been transduced to express human cytochrome P4502E1 (CYP2E1). Arachidonic acid
produced a concentration-and time-dependent toxicity to Hep G2-MV2E1-9 cells, which
express CYP2E1, but little or no toxicity was found with control Hep G2-MV-5 cells, which
were infected with retrovirus lacking human CYP2E1 cDNA. In contrast to arachidonic acid …