Immune complex specific for the pancreatic duct antigen in patients with idiopathic chronic pancreatitis and Sjögren syndrome
M Onodera, K Okazaki, M Morita, I Nishimori… - …, 1994 - Taylor & Francis
M Onodera, K Okazaki, M Morita, I Nishimori, Y Yamamoto
Autoimmunity, 1994•Taylor & FrancisCirculating immune complexes (ICs) containing the pancreatic antigen against SP3–1
monoclonal antibody were measured in patients with idiopathic chronic pancreatitis (ICP)
and Sjögren syndrome (SjS) by Raji cell and solid-phase radioimmuno-assays (RIA). The
mean serum levels of ICs measured by solid-phase RIA were significantly higher in patients
with ICP (n= 23) and SjS (n= 21) than control (n= 15, p< 0.05, p< 0.02, respectively). ICs
were positive in 10 patients with ICP (43%) and 12 SjS patients (57%). Raji cell assay also …
monoclonal antibody were measured in patients with idiopathic chronic pancreatitis (ICP)
and Sjögren syndrome (SjS) by Raji cell and solid-phase radioimmuno-assays (RIA). The
mean serum levels of ICs measured by solid-phase RIA were significantly higher in patients
with ICP (n= 23) and SjS (n= 21) than control (n= 15, p< 0.05, p< 0.02, respectively). ICs
were positive in 10 patients with ICP (43%) and 12 SjS patients (57%). Raji cell assay also …
Circulating immune complexes (ICs) containing the pancreatic antigen against SP3–1 monoclonal antibody were measured in patients with idiopathic chronic pancreatitis (ICP) and Sjögren syndrome (SjS) by Raji cell and solid-phase radioimmuno-assays (RIA). The mean serum levels of ICs measured by solid-phase RIA were significantly higher in patients with ICP (n = 23) and SjS (n = 21) than control (n = 15, p < 0.05, p < 0.02, respectively). ICs were positive in 10 patients with ICP (43%) and 12 SjS patients (57%). Raji cell assay also revealed a significantly higher serum ICs levels in patients with ICP (n = 17) and SjS (n = 12) compared with those of control (n = 7, p < 0.025, p < 0.005, respectively). Seven patients with ICP (41%) and 8 SjS patients (67%) had positive ICs. This was in contrast to the normal level of ICs in patients with alcoholic chronic pancreatitis, primary biliary cirrhosis, and chronic thyroiditis. Our analysis demonstrated a significant and positive relationship between RIA and Raji cell assay (r = 0.70, p < 0.05). Our results suggest that ICs specific for SP3–1 may play a role in the pathophysiology of ICP and SjS.
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