Antigen presentation by MHC class II molecules: invariant chain function, protein trafficking, and the molecular basis of diverse determinant capture
F Castellino, G Zhong, RN Germain - Human immunology, 1997 - Elsevier
Major histocompatibility complex class II molecules are heterodimeric integral membrane
proteins whose primary function is the presentation of antigenic peptides derived from
proteins entering the endocytic pathway to CD4+ T lymphocytes. To accomplish this
physiologic function, class II molecules must assemble in the secretory pathway without
undergoing irreversible ligand association at that site, traffic efficiently to the endocytic
pathway, and productively interact with protein ligands in these organelles before their …
proteins whose primary function is the presentation of antigenic peptides derived from
proteins entering the endocytic pathway to CD4+ T lymphocytes. To accomplish this
physiologic function, class II molecules must assemble in the secretory pathway without
undergoing irreversible ligand association at that site, traffic efficiently to the endocytic
pathway, and productively interact with protein ligands in these organelles before their …