[HTML][HTML] Low density lipoprotein oxidation and its pathobiological significance
D Steinberg - Journal of Biological Chemistry, 1997 - ASBMB
Background The fact that low density lipoprotein (LDL) 1 is extremely susceptible to
oxidative damage has been known for some time (1, 2), but until quite recently this was
primarily a nuisance for the student of lipoprotein metabolism. It now appears that oxidation
of LDL plays a significant role in atherogenesis. Beginning in the 1980s evidence began to
accumulate that cholesterol accumulation in the developing atherosclerotic lesion was
probably not due to the uptake of native LDL by way of the Brown/Goldstein LDL receptor …
oxidative damage has been known for some time (1, 2), but until quite recently this was
primarily a nuisance for the student of lipoprotein metabolism. It now appears that oxidation
of LDL plays a significant role in atherogenesis. Beginning in the 1980s evidence began to
accumulate that cholesterol accumulation in the developing atherosclerotic lesion was
probably not due to the uptake of native LDL by way of the Brown/Goldstein LDL receptor …