Reovirus infections in human volunteers.
L Rosen, HE Evans, A Spickard - American journal of hygiene, 1963 - cabdirect.org
L Rosen, HE Evans, A Spickard
American journal of hygiene, 1963•cabdirect.org27 adult male volunteers were given one dose of one reovirus serotype intranasally. They
were isolated in groups of 3, and each member of a group was given the same serotype. In
all 9 volunteers received each serotype. Attempts to select only volunteers who had low
hagglutination-inhibiting antibodies largely failed. 3 out of each group of 9 volunteers who
received types 1 and 2, and 2 out of 9 who received type 3 were ill. Those receiving types 1
and 2 had malaise, rhinorrhoea, cough, pharyngitis and headache. The illness lasted 4 to 7 …
were isolated in groups of 3, and each member of a group was given the same serotype. In
all 9 volunteers received each serotype. Attempts to select only volunteers who had low
hagglutination-inhibiting antibodies largely failed. 3 out of each group of 9 volunteers who
received types 1 and 2, and 2 out of 9 who received type 3 were ill. Those receiving types 1
and 2 had malaise, rhinorrhoea, cough, pharyngitis and headache. The illness lasted 4 to 7 …
Abstract
27 adult male volunteers were given one dose of one reovirus serotype intranasally. They were isolated in groups of 3, and each member of a group was given the same serotype. In all 9 volunteers received each serotype. Attempts to select only volunteers who had low hagglutination-inhibiting antibodies largely failed.
3 out of each group of 9 volunteers who received types 1 and 2, and 2 out of 9 who received type 3 were ill. Those receiving types 1 and 2 had malaise, rhinorrhoea, cough, pharyngitis and headache. The illness lasted 4 to 7 days. Those receiving type 3 had rhinitis. 3 out of 18 volunteers who were given a placebo had a mild respiratory illness.
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