[HTML][HTML] The Mouse Gene for Vascular Endothelial Growth Factor: GENOMIC STRUCTURE, DEFINITION OF THE TRANSCRIPTIONAL UNIT, AND …

DT Shima, M Kuroki, U Deutsch, YS Ng… - Journal of Biological …, 1996 - ASBMB
We describe the genomic organization and functional characterization of the mouse gene
encoding vascular endothelial growth factor (VEGF), a polypeptide implicated in embryonic
vascular development and postnatal angiogenesis. The coding region for mouse VEGF is
interrupted by seven introns and encompasses approximately 14 kilobases. Organization of
exons suggests that, similar to the human VEGF gene, alternative splicing generates the 120-
, 164-, and 188-amino acid isoforms, but does not predict a fourth VEGF isoform …