Osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of OI

LW Fisher, MA Drum, PG Robey, KM Conn… - Calcified tissue …, 1987 - Springer
LW Fisher, MA Drum, PG Robey, KM Conn, JD Termine
Calcified tissue international, 1987Springer
Samples of human osteogenesis imperfecta (OI) bone were analyzed for osteonectin
content by SDS gel electrophoresis and immunodetection on Western blots. The OI bone
osteonectin content varied from normal to severely depressed. Previously, we showed that
two clinically identical but genetically unrelated bovine methods of OI were differentiated
biochemically by their bone osteonectin content: one OI mode had normal bone osteonectin
while the other was severely depressed in this parameter. The data in this pilot study …
Summary
Samples of human osteogenesis imperfecta (OI) bone were analyzed for osteonectin content by SDS gel electrophoresis and immunodetection on Western blots. The OI bone osteonectin content varied from normal to severely depressed. Previously, we showed that two clinically identical but genetically unrelated bovine methods of OI were differentiated biochemically by their bone osteonectin content: one OI mode had normal bone osteonectin while the other was severely depressed in this parameter. The data in this pilot study suggest that further investigation of bone osteonectin content may prove useful in the clinical assessment of human OI cases.
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