Leptin binding in the arcuate nucleus is increased during fasting
DG Baskin, JF Breininger, S Bonigut, MA Miller - Brain research, 1999 - Elsevier
DG Baskin, JF Breininger, S Bonigut, MA Miller
Brain research, 1999•ElsevierThe arcuate nucleus (ARC) mediates the anorexic effects of leptin and expresses the long
form (Ob-Rb) of the leptin receptor. To determine whether ARC leptin binding increases
when plasma leptin levels are low during fasting,[125I]-leptin specific binding to rat brain
slices was measured by quantitative autoradiography.[125I]-leptin specific binding was
dense in the ARC and increased 2-fold after a 48-h fast (P< 0.001). These findings suggest
that leptin receptor binding in the ARC is upregulated during fasting and that fasting …
form (Ob-Rb) of the leptin receptor. To determine whether ARC leptin binding increases
when plasma leptin levels are low during fasting,[125I]-leptin specific binding to rat brain
slices was measured by quantitative autoradiography.[125I]-leptin specific binding was
dense in the ARC and increased 2-fold after a 48-h fast (P< 0.001). These findings suggest
that leptin receptor binding in the ARC is upregulated during fasting and that fasting …
The arcuate nucleus (ARC) mediates the anorexic effects of leptin and expresses the long form (Ob-Rb) of the leptin receptor. To determine whether ARC leptin binding increases when plasma leptin levels are low during fasting, [125I ]-leptin specific binding to rat brain slices was measured by quantitative autoradiography. [125I ]-leptin specific binding was dense in the ARC and increased 2-fold after a 48-h fast (P<0.001). These findings suggest that leptin receptor binding in the ARC is upregulated during fasting and that fasting changes the sensitivity of the ARC to leptin.
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