The genetic susceptibility to Graves' disease
Y Tomer, TF Davies - Baillière's clinical endocrinology and metabolism, 1997 - Elsevier
Graves' disease (GD) develops as a result of a complex interaction between genetic
susceptibility genes and likely environmental factors. Most epidemiological data support an
important genetic contribution to the development of GD. The concordance rate of GD in
monozygotic twins is 30–60% and in dizygotic twins 3–9%, and thyroid autoantibodies have
been reported in up to 50% of the siblings of patients with GD. For many years now, HLA
studies have consistently shown an increased frequency of HLA-DR3 in Caucasian patients …
susceptibility genes and likely environmental factors. Most epidemiological data support an
important genetic contribution to the development of GD. The concordance rate of GD in
monozygotic twins is 30–60% and in dizygotic twins 3–9%, and thyroid autoantibodies have
been reported in up to 50% of the siblings of patients with GD. For many years now, HLA
studies have consistently shown an increased frequency of HLA-DR3 in Caucasian patients …