Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells.
M Hengstschläger, M Knöfler, EW Müllner… - Journal of Biological …, 1994 - ASBMB
We compared the cell cycle regulation of thymidine kinase (TK) after centrifugal elutriation in
normal human and mouse cells (primary cells, diploid fibroblasts) with its expression in cells
transformed with different DNA tumor viruses. Normal cells showed a rise of TK enzyme
activity near the G1/S boundary, which peaked in S phase, and in G2 returned
approximately to the level of G1. Conversely, in cells derived from viral transformation, TK
activity remained high throughout S and G2 phases, although it was induced to a …
normal human and mouse cells (primary cells, diploid fibroblasts) with its expression in cells
transformed with different DNA tumor viruses. Normal cells showed a rise of TK enzyme
activity near the G1/S boundary, which peaked in S phase, and in G2 returned
approximately to the level of G1. Conversely, in cells derived from viral transformation, TK
activity remained high throughout S and G2 phases, although it was induced to a …