[HTML][HTML] The role of α1β1 integrin in wound contraction: a quantitative analysis of liver myofibroblasts in vivo and in primary culture
L Racine-Samson, DC Rockey, DM Bissell - Journal of Biological Chemistry, 1997 - ASBMB
An unresolved question in wound contraction concerns the identity of integrins mediating the
attachment of tissue myofibroblasts to matrix in the injury site. Previous studies with cell lines
have focussed on α1β1 and α2β1, the principal collagen-binding integrins, but have yielded
conflicting data. We have examined this issue in wound healing in the liver, isolating the
myofibroblast population (activated stellate cells) and quantitating expression of the α1 and
α2 integrin subunits during the in vivo injury. Normal stellate cells displayed α1 but no …
attachment of tissue myofibroblasts to matrix in the injury site. Previous studies with cell lines
have focussed on α1β1 and α2β1, the principal collagen-binding integrins, but have yielded
conflicting data. We have examined this issue in wound healing in the liver, isolating the
myofibroblast population (activated stellate cells) and quantitating expression of the α1 and
α2 integrin subunits during the in vivo injury. Normal stellate cells displayed α1 but no …
